2. at Colts, week 15, won 16-10
For the first time in franchise history the Texans won in Indianapolis. It was not a pretty game for either side but ultimately the Texans got it done. T.J. Yates started the game but was replaced by Brandon Weeden who threw for 105 yards in relief and a touchdown to win the game in the fourth quarter not long after arriving in Houston after being cut by Dallas. Down 10-6 Weeden found Jaelen Strong to go up by three and then Nick Novak added three more before the defense sealed the win. The defense limited the Colts to just 190 yards of offense in the game. The win broke a two game losing streak to the Bills and Patriots and started a three game winning streak to end the regular season against each of their AFC South opponents.