AFC South Preview: Week 3

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Sep 15, 2013; Seattle, WA, USA; San Francisco 49ers quarterback Colin Kaepernick (7) passes against the Seattle Seahawks during the fourth quarter at CenturyLink Field. Mandatory Credit: Joe Nicholson-USA TODAY Sports

Indianapolis Colts (1-1) at San Francisco 49ers (1-1)
This might be my favorite game on the schedule this weekend. This game features two young quarterbacks in the Colts’ Andrew Luck and the 49ers’ Colin Kaepernick, plus both teams are coming off losses, and both play for very good teams.

The teams have top veteran wide receivers in Reggie Wayne for the Colts and Anquan Boldin of the 49ers, which can make life rough on opposing defenses. Also watch out for T.Y. Hilton of the Colts, as the second-year players could be a big factor in the game. He’s quietly becoming a go-to target for Luck.

Defensively for these two teams, I honestly don’t know what to expect after the way the Seahaeks were able to get 29 on the 49ers in Week 2, and the Colts were no better by not being able to stop the Buffalo Bills at the end of their game, which contributed to the loss.

This will be an interesting, and well played contest for sure, but I’m guessing this game comes down to quarterback play.